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prof. RNDr. Michaela Wimmerová, Ph.D.

Research Group Leader Senior, Michaela Wimmerová Research Group

office: bldg. C04/119
Kamenice 753/5
625 00 Brno

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phone: +420 549 49 8166
e‑mail:
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Basic information
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Curriculum vitae

Person Identification
  • Prof. RNDr. Michaela Wimmerová, Ph.D.
Institution
  • Department of Biochemistry, Faculty of science, Masaryk University, Brno, Czech Republic
  • National Centre for Biomolecular Research, Faculty of science, Masaryk University, Brno, Czech Republic
  • Central European Institute of Technology, Masaryk University, Brno, Czech Republic
Current position
  • Professor
Education and academic qualifications
  • 2013: Full professor, Masaryk University, Brno (Biochemistry)
  • 2007: Associate professor, Masaryk University, Brno (Biochemistry)
  • 1996: Asistant professor, Masaryk University, Brno (Biochemistry)
  • 1996: Ph.D. Masaryk University, Brno (Biochemistry)
  • 1991: M.Sc. Masaryk University, Brno (Biochemistry)
Professional experience
  • 2013          Professor, Department of Biochemistry, Masaryk University, Brno, Czech Republic
  • 2011-         Head of Biomolecular Interactions and Crystallization Core Facility, CEITEC MU Brno
  • 2011-         Group leader, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
  • 2007-2013   Associate Professor, Department of Biochemistry, Masaryk university, Brno, Czech Republic
  • 2000-     ~  Group leader, National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic
  • 1996-2007   Assistant Professor, Masaryk University Brno, Czech Republic
  • 1991-1996   Researcher, Masaryk University Brno, Czech Republic
Teaching activities
  • Basic Course on Clinical Biochemistry, Course of Chemoinformatics and Bioinformatics, Practical Course Bioinformatics in Practise, Advanced bioinformatics, Courses from Methods in Clinical Biochemistry, training Separation Methods of Biomolecules and Immunochemical methods. Courses on Thermodynamics of biomolecular interactions.
  • Member of academic boards for PhD studies at Masaryk University, Brno, Brno Technical University, Charles University, Prague and University of Palacky, Olomouc.
  • Supervision of PhD, Master and Bachelor theses.
Research activities
  • Structural biology, glycobiochemistry, biomolecular interactions, structure-functional genomics, bioinformatics, separation and analytical techniques in biochemistry. Initially focused on plant and microbial enzymes and their utilizing in clinical and industrial applications, construction of enzyme biosensors, and preparation of specially labelled proteins for NMR studies of protein-ligand interactions. Later on, oriented to studies of enzymes participating in the degradation of xenobiotics in the environment.
  • At present, research has been focused on glycobiochemistry, oriented mainly to bioinformatics, structure-function studies of proteins, which participate on glycoconjugates synthesis (glycosyltransferases) or recognition (lectins) and are related to pathogenesis.
  • ResearcherID A-4114-2010, OrcidID: 0000-0002-7108-4198
Scientific stays abroad
  • short-time – University of Lund (Sweden), University of Bayreuth (Germany), The Royal Veterinary and Agricultural University, Food Technology, Copenhagen (Denmark), The Scripps Research Institute, La Jolla (USA), University of San Diego (USA)
  • long-time - Centre de Recherches sur les Macromolécules Végétales (CERMAV), CNRS, Grenoble, France (2001-2002)
Memberships and academic services to the community
  • Czech Science Foundation, Member of the Evaluation Committee (2017-)
  • Association of Resources for Biophysical Research in Europe, member of the Management Committee (2015-)
  • National representative in International Glycoconjugate Organisation (IGO), Member of the Board (2011-)
  • Glycobiology, Member of the Editorial board (2011-)
  • Czech Science Foundation, Member of the Evaluation Committee (2011–2014)
  • Federation of European Biochemical Societies (FEBS) – member of the Fellowships committee (2010-2013)
  • Czech Society for Biochemistry and Molecular Biology – member of the National board (2008-); Vice-chair (2017-)
  • Czech Chemical Society (1998-); Treasurer of the Brno branch (1998-2010)
  • Member of American Society for Biochemistry and Molecular Biology, Czech Society of Clinical Chemistry, Society for Glycobiology
Selected Publications (more on Orcid.org: 0000-0002-7108-4198)
  • FUJDIAROVÁ, Eva, Josef HOUSER, Pavel DOBEŠ, Gita PAULÍKOVÁ, Nikolaj KONDAKOV, Leonid KONONOV, Pavel HYRŠL a Michaela WIMMEROVÁ. Heptabladed b-propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O-methylated sugars and influence the host immune system. The FEBS Journal. Hoboken: Wiley, 2021, roč. 288, č. 4, s. 1343-1365. ISSN 1742-464X. Dostupné z: https://dx.doi.org/10.1111/febs.15457. URL info
  • HOUSER, Josef, Jana KOSOUROVÁ, Monika KUBÍČKOVÁ a Michaela WIMMEROVÁ. Development of 48-condition buffer screen for protein stability assessment. European Biophysics Journal With Biophysics Letters. NEW YORK: SPRINGER, 2021, roč. 50, 3-4, s. 461-471. ISSN 0175-7571. Dostupné z: https://dx.doi.org/10.1007/s00249-021-01497-6. URL info
  • GAJDOŠ, Lukáš, Matthew P. BLAKELEY, Atul KUMAR, Michaela WIMMEROVÁ, Michaela HAERTLEIN, Trevor V. FORSYTH, Anne IMBERTY a Juliette M. DEVOS. Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions. Structure. CAMBRIDGE: CELL PRESS, 2021, roč. 29, č. 9, s. "1003"-"1013.e4", 15 s. ISSN 0969-2126. Dostupné z: https://dx.doi.org/10.1016/j.str.2021.03.003. URL info
  • SÝKOROVÁ, Petra, Jitka NOVOTNÁ, Gabriel DEMO, Guillaume POMPIDOR, Eva DUBSKÁ, Jan KOMÁREK, Eva FUJDIAROVÁ, Josef HOUSER, Lucia HÁRONÍKOVÁ, Annabelle VARROT, Nadya SHILOVA, Anne IMBERTY, Nicolai BOVIN, Martina POKORNÁ a Michaela WIMMEROVÁ. Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold. International journal of biological macromolecules. Amsterdam: Elsevier Science BV, 2020, roč. 152, JUN, s. 1113-1124. ISSN 0141-8130. Dostupné z: https://dx.doi.org/10.1016/j.ijbiomac.2019.10.200. URL info
  • KOTSARENKO, Kateryna, Pavlina VECHTOVA, Zuzana HAMMEROVÁ, Natália LANGOVÁ, Lenka MALINOVSKÁ, Michaela WIMMEROVÁ, Jan STERBA a Libor GRUBHOFFER. Newly identified DNA methyltransferases of Ixodes ricinus ticks. Ticks and Tick-borne Diseases. Munich: Elsevier GmbH, 2020, roč. 11, č. 2, s. 101348-101357. ISSN 1877-959X. Dostupné z: https://dx.doi.org/10.1016/j.ttbdis.2019.101348. URL info
  • HOUSER, Josef, Stanislav KOZMON, Deepti MISHRA, Zuzana HAMMEROVÁ, Michaela WIMMEROVÁ a Jaroslav KOČA. The CH-pi Interaction in Protein-Carbohydrate Binding: Bioinformatics and In Vitro Quantification. Chemistry - A European Journal. WEINHEIM: Wiley, 2020, roč. 26, č. 47, s. 10769-10780. ISSN 0947-6539. Dostupné z: https://dx.doi.org/10.1002/chem.202000593. URL info
  • GEISSNER, Andreas, Anika REINHARDT, Christoph RADEMACHER, Timo JOHANNSSEN, João MONTEIRO, Bernd LEPENIES, Michel THEPAUT, Franck FIESCHI, Jana MRÁZKOVÁ, Michaela WIMMEROVÁ, Frank SCHUHMACHER, Sebastian GOTZE, Dan GRUNSTEIN, Xiaoqiang GUO, Heung Sik HAHM, Jeyakumar KANDASAMY, Daniele LEONORI, Christopher E. MARTIN, Sharavathi G. PARAMESWARAPPA, Sandip PASARI, Mark K. SCHLEGEL, Hidenori TANAKA, Guozhi XIAO, You YANG, Claney L. PEREIRA, Chakkumkal ANISH a Peter H. SEEBERGER. Microbe-focused glycan array screening platform. Proceedings of the National Academy of Sciences of the United States of America. WASHINGTON: NATL ACAD SCIENCES, 2019, roč. 116, č. 6, s. 1958-1967. ISSN 0027-8424. Dostupné z: https://dx.doi.org/10.1073/pnas.1800853116. URL info
  • THAI LE, Son, Lenka MALINOVSKÁ, Michaela VAŠKOVÁ, Erika MEZO, Viktor KELEMEN, Anikó BORBÁS, Petr HODEK, Michaela WIMMEROVÁ a Magdolna CSÁVÁS. Investigation of the Binding Affinity of a Broad Array of L-Fucosides with Six Fucose-Specific Lectins of Bacterial and Fungal Origin. Molecules. Mayer und Muller, 2019, roč. 24, č. 12, s. 1-17. ISSN 1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules24122262. URL info
  • MRÁZKOVÁ, Jana, Lenka MALINOVSKÁ a Michaela WIMMEROVÁ. Microscopy examination of red blood and yeast cell agglutination induced by bacterial lectins. PLOS ONE. Public Library of Science, 2019, roč. 14, č. 7, s. 1-23. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0220318. URL info
  • PAULÍKOVÁ, Gita, Josef HOUSER, Martina KASAKOVA, Beata OROSZOVA, Benedetta BERTOLOTTI, Kamil PARKAN, Jitka MORAVCOVÁ a Michaela WIMMEROVÁ. Fucosylated inhibitors of recently identified bangle lectin from Photorhabdus asymbiotica. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2019, roč. 9, č. 1, s. 14904-14915. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-019-51357-9. URL info
  • MALINOVSKÁ, Lenka, Son THAI LE, Mihály HERCZEG, Michaela VAŠKOVÁ, Josef HOUSER, Eva FUJDIAROVÁ, Jan KOMÁREK, Petr HODEK, Anikó BORBÁS, Michaela WIMMEROVÁ a Magdolna CSÁVÁS. Synthesis of beta-D-galactopyranoside-Presenting Glycoclusters, Investigation of Their Interactions with Pseudomonas aeruginosa Lectin A (PA-IL) and Evaluation of Their Anti-Adhesion Potential. Biomolecules. MDPI, 2019, roč. 9, č. 11, s. 686-707. ISSN 2218-273X. Dostupné z: https://dx.doi.org/10.3390/biom9110686. URL info
  • FALTINEK, Lukáš, Eva FUJDIAROVÁ, Filip MELICHER, Josef HOUSER, Martina KAŠÁKOVÁ, Nikolay KONDAKOV, Leonid KONONOV, Kamil PARKAN, Sébastien VIDAL a Michaela WIMMEROVÁ. Lectin PLL3, a Novel Monomeric Member of the Seven-Bladed beta-Propeller Lectin Family. Molecules. Basel: MDPI, 2019, roč. 24, č. 24, s. 1-20. ISSN 1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules24244540. Full Text info
  • BONNARDEL, Francois, Atul KUMAR, Michaela WIMMEROVÁ, Martina LAHMANN, Serge PEREZ, Annabelle VARROT, Frederique LISACEK a Anne IMBERTY. Architecture and Evolution of Blade Assembly in beta-propeller Lectins. Structure. CAMBRIDGE: CELL PRESS, 2019, roč. 27, č. 5, s. 764-775. ISSN 0969-2126. Dostupné z: https://dx.doi.org/10.1016/j.str.2019.02.002. URL info
  • MRÁZKOVÁ, Jana, Lenka MALINOVSKÁ a Michaela WIMMEROVÁ. Step-by-Step In Vitro Mutagenesis: Lessons From Fucose-Binding Lectin PA-IIL. In Andrew Reeves. In Vitro Mutagenesis Methods and Protocols. New York: Springer Science + Business Media LLC, 2017, s. 399-419. Methods in Molecular Biology sv. 1498. ISBN 978-1-4939-6470-3. Dostupné z: https://dx.doi.org/10.1007/978-1-4939-6472-7. info
  • CSÁVÁS, Magdolna, Lenka MALINOVSKÁ, Florent PERRET, Milán GYURKÓ, Zita Tünde ILLYÉS, Michaela WIMMEROVÁ a Anikó BORBÁS. Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia. Carbohydrate Research. Elsevier Science, 2017, roč. 437, January 2017, s. 1-8. ISSN 0008-6215. Dostupné z: https://dx.doi.org/10.1016/j.carres.2016.11.008. URL info
  • JANČAŘÍKOVÁ, Gita, Josef HOUSER, Pavel DOBEŠ, Gabriel DEMO, Pavel HYRŠL a Michaela WIMMEROVÁ. Characterization of novel bangle lectin from Photorhabdus asymbiotica with dual sugar-binding specificity and its effect on host immunity. PLoS Pathogens. San Francisco: Public Library of Science, 2017, roč. 13, č. 8, s. 1-28. ISSN 1553-7366. Dostupné z: https://dx.doi.org/10.1371/journal.ppat.1006564. URL info
  • KERR, Sheena C, Gregory J FISCHER, Meenal SINHA, Orla MCCOBE, Jonathan M. PALMER, Tsokyi CHOERA, Fang Yun LIM, Michaela WIMMEROVÁ, Stephen D. CARRINGTON, Shaopeng YUAN, Clifford A. LOWELL, Stefan OSCARSON, Nancy P. KELLER a John V. FAHY. FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection. PLoS Pathog. 2016, roč. 12, č. 4, s. "nestrankovano", 20 s. ISSN 1553-7366. Dostupné z: https://dx.doi.org/10.1371/journal.ppat.1005555. info
  • KUMAR, Atul, Petra SÝKOROVÁ, Gabriel DEMO, Pavel DOBEŠ, Pavel HYRŠL a Michaela WIMMEROVÁ. A Novel Fucose-Binding Lectin from Photorhabdus luminescens (PLL) with an Unusual Heptabladed beta-Propeller Tetrameric Structure. The Journal of Biological Chemistry. Bethesda: American Society for Biochemistry and Molecular Biology, 2016, roč. 291, č. 48, s. 25032-25049. ISSN 0021-9258. Dostupné z: https://dx.doi.org/10.1074/jbc.M115.693473. URL info
  • NORTON, Pamela, Mary Ann COMUNALE, Harmin HERRERA, Mengjun WANG, Josef HOUSER, Michaela WIMMEROVÁ, Patrick R ROMANO a Anand MEHTA. Development and application of a novel recombinant Aleuria aurantia lectin with enhanced core fucose binding for identification of glycoprotein biomarkers of hepatocellular carcinoma. Proteomics. HOBOKEN: Wiley-Blackwell, 2016, roč. 16, č. 24, s. 3126-3136. ISSN 1615-9853. Dostupné z: https://dx.doi.org/10.1002/pmic.201600064. URL info
  • SEHNAL, David, Radka SVOBODOVÁ VAŘEKOVÁ, Lukáš PRAVDA, Crina-Maria IONESCU, Stanislav GEIDL, Vladimír HORSKÝ, Deepti JAISWAL, Michaela WIMMEROVÁ a Jaroslav KOČA. ValidatorDB: database of up-to-date validation results for ligands and non-standard residues from the Protein Data Bank. Nucleic Acids Research. United Kingdom: Oxford University Press, 2015, roč. 43, D1, s. "D369"-"D375", 7 s. ISSN 0305-1048. Dostupné z: https://dx.doi.org/10.1093/nar/gku1118. URL info
  • HOUSER, Josef, Jan KOMÁREK, Gianluca CIOCI, Annabelle VARROT, Anne IMBERTY a Michaela WIMMEROVÁ. Structural insights into Aspergillus fumigatus lectin specificity: AFL binding sites are functionally non-equivalent. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY. HOBOKEN: WILEY-BLACKWELL, 2015, roč. 71, March, s. 442-453. ISSN 1399-0047. Dostupné z: https://dx.doi.org/10.1107/S1399004714026595. URL info
  • SVOBODOVÁ VAŘEKOVÁ, Radka, Deepti JAISWAL, David SEHNAL, Crina-Maria IONESCU, Stanislav GEIDL, Lukáš PRAVDA, Vladimír HORSKÝ, Michaela WIMMEROVÁ a Jaroslav KOČA. MotiveValidator: interactive web-based validation of ligand and residue structure in biomolecular complexes. Nucleic Acids Research. Oxford, UK: Oxford University Press, 2014, roč. 42, W1, s. "W227"-"W233", 7 s. ISSN 0305-1048. Dostupné z: https://dx.doi.org/10.1093/nar/gku426. URL info
  • DEMO, Gabriel, Veronika PAPOUŠKOVÁ, Jan KOMÁREK, Pavel KADEŘÁVEK, Olga OTRUSINOVÁ, Pavel SRB, Alzbeta RABATINOVA, Libor KRÁSNÝ, Lukáš ŽÍDEK, Vladimír SKLENÁŘ a Michaela WIMMEROVÁ. X-ray vs. NMR structure of N-terminal domain of delta-subunit of RNA polymerase. Journal of Structural Biology. San Diego: Academic Press, 2014, roč. 187, č. 2, s. 174-186. ISSN 1047-8477. Dostupné z: https://dx.doi.org/10.1016/j.jsb.2014.06.001. URL info
  • DEMO, Gabriel, Veronika HORSKÁ, Barbora FLIEDROVA, Jakub ŠTĚPÁN, Jaroslav KOČA, Lenka WEIGNEROVA, Vladimír KŘEN a Michaela WIMMEROVÁ. Protein engineering study of beta-mannosidase to set up a potential chemically efficient biocatalyst. Glycobiology. Oxford: Oxford University Press, 2014, roč. 24, č. 12, s. 1301-1311. ISSN 0959-6658. Dostupné z: https://dx.doi.org/10.1093/glycob/cwu074. URL info
  • ADAMOVÁ, Lenka, Lenka MALINOVSKÁ a Michaela WIMMEROVÁ. New sensitive detection method for lectin hemagglutination using microscopy. Microscopy research and technique. USA: Wiley-Blackwell, 2014, roč. 77, č. 10, s. 841-849. ISSN 1059-910X. Dostupné z: https://dx.doi.org/10.1002/jemt.22407. URL info
  • KŘÍŽ, Zdeněk, Jan ADAM, Jana MRÁZKOVÁ, Petros ZOTOS, Thomais CHATZIPAVLOU, Michaela WIMMEROVÁ a Jaroslav KOČA. Engineering the Pseudomonas aeruginosa II lectin: designing mutants with changed affinity and specificity. Journal of Computer-Aided Molecular Design. Dordrecht (Netherlands): Springer International Publishing, 2014, roč. 28, č. 9, s. 951-960. ISSN 0920-654X. Dostupné z: https://dx.doi.org/10.1007/s10822-014-9774-7. URL info
  • DEMO, Gabriel, Barbora FLIEDROVA, Lenka WEIGNEROVA a Michaela WIMMEROVÁ. Crystallization and preliminary X-ray crystallographic analysis of recombinant beta-mannosidase from Aspergillus niger. Acta crystallographica. Section F. Hoboken: WILEY-BLACKWELL, 2013, roč. 69, Mar, s. 288-291. ISSN 1744-3091. Dostupné z: https://dx.doi.org/10.1107/S1744309113002522. info
  • TVAROŠKA, Igor, Stanislav KOZMON, Michaela WIMMEROVÁ a Jaroslav KOČA. A QM/MM Investigation of the Catalytic Mechanism of Metal-Ion-Independent Core 2 beta1,6-N-Acetylglucosaminyltransferase. Chemistry - A European Journal. Weinheim: WILEY-VCH Verlag, 2013, roč. 19, č. 25, s. 8153-8162. ISSN 0947-6539. Dostupné z: https://dx.doi.org/10.1002/chem.201300383. URL info
  • HOUSER, Josef, Jan KOMÁREK, Nikola KOSTLÁNOVÁ, Gianluca CIOCI, Annabelle VARROT, Sheena KERR, Martina LAHMANN, Viviane BALLOY, John FAHY, Michel CHIGNARD, Anne IMBERTY a Michaela WIMMEROVÁ. A Soluble Fucose-Specific Lectin from Aspergillus fumigatus Conidia - Structure, Specificity and Possible Role in Fungal Pathogenicity. PLOS ONE. Public Library of Science, 2013, roč. 8, č. 12, s. 1-15. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0083077. Original article web page - full text free. info
  • FROMMEL, Jan, Miroslav SOURAL, Martina TYLICHOVÁ, David KOPEČNÝ, Gabriel DEMO, Michaela WIMMEROVÁ a Marek ŠEBELA. Plant aminoaldehyde dehydrogenases oxidize a wide range of nitrogenous heterocyclic aldehydes. Amino Acids. Wien: Springer-Verlag, 2012, roč. 43, č. 3, s. 1189-1202. ISSN 0939-4451. Dostupné z: https://dx.doi.org/10.1007/s00726-011-1174-x. URL info
  • MISHRA, Sushil Kumar, Gabriel DEMO, Jaroslav KOČA a Michaela WIMMEROVÁ. In Silico Engineering of Proteins that Recognize Small Molecules. In Prof. Pravin Kaumaya. Protein Engineering. Neuveden: InTech - Open Access Publisher, 2012, s. 307-344. ISBN 978-953-51-0037-9. URL URL info
  • SEHNAL, David, Radka SVOBODOVÁ VAŘEKOVÁ, Heinrich J. HUBER, Stanislav GEIDL, Crina-Maria IONESCU, Michaela WIMMEROVÁ a Jaroslav KOČA. SiteBinder: An improved approach for comparing multiple protein structural motifs. Journal of Chemical Information and Modeling. 2012, roč. 52, č. 2, s. 343–359. ISSN 1549-9596. Dostupné z: https://dx.doi.org/10.1021/ci200444d. info
  • MISHRA, Sushil Kumar, Jan ADAM, Michaela WIMMEROVÁ a Jaroslav KOČA. In Silico Mutagenesis and Docking Study of Ralstonia solanacearum RSL Lectin: Performance of Docking Software To Predict Saccharide Binding. Journal of Chemical Information and Modeling. WASHINGTON: AMER CHEMICAL SOC, 2012, roč. 52, č. 5, s. 1250-1261. ISSN 1549-9596. Dostupné z: https://dx.doi.org/10.1021/ci200529n. URL info
  • MARCHETTI, Roberta, Lenka MALINOVSKÁ, Emilie LAMEIGNERE, Lenka ADAMOVÁ, Cristina DE CASTRO, Gianluca CIOCI, Christian STANETTY, Paul KOSMA, Antonio MOLINARO, Michaela WIMMEROVÁ, Anne IMBERTY a Alba SILIPO. Burkholderia cenocepacia lectin A binding to heptoses from the bacterial lipopolysaccharide. Glycobiology. Oxford: Oxford University Press, 2012, roč. 22, č. 10, s. 1387-1398. ISSN 0959-6658. Dostupné z: https://dx.doi.org/10.1093/glycob/cws105. URL info
  • CECIONI, Samy, Jean-Pierre PRALY, Susan E MATTHEWS, Michaela WIMMEROVÁ, Anne IMBERTY a Sebastien VIDAL. Rational Design and Synthesis of Optimized Glycoclusters for Multivalent Lectin-Carbohydrate Interactions: Influence of the Linker Arm. Chemistry - A European Journal. WEINHEIM: WILEY-VCH, 2012, roč. 18, č. 20, s. 6250-6263. ISSN 0947-6539. Dostupné z: https://dx.doi.org/10.1002/chem.201200010. URL info
  • AUDFRAY, Aymeric, Julie CLAUDINON, Saida ABOUNIT, Nathalie RUVOEN-CLOUET, Goran LARSON, David F SMITH, Michaela WIMMEROVÁ, Jacques LE PENDU, Winfried ROEMER, Annabelle VARROT a Anne IMBERTY. Fucose-binding Lectin from Opportunistic Pathogen Burkholderia ambifaria Binds to Both Plant and Human Oligosaccharidic Epitopes. Journal of Biological Chemistry. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., 2012, roč. 287, č. 6, s. 4335-4347. ISSN 0021-9258. Dostupné z: https://dx.doi.org/10.1074/jbc.M111.314831. URL info
  • TVAROŠKA, Igor, Stanislav KOZMON, Michaela WIMMEROVÁ a Jaroslav KOČA. Substrate Assisted Catalytic Mechanism of O GlcNAc Transferase Discovered by Quantum Mechanics/Molecular Mechanics Investigation. J. Am. Chem. Soc. Washington: American Chemical Society, 2012, roč. 134, č. 37, s. 15563-15571. ISSN 0002-7863. Dostupné z: https://dx.doi.org/10.1021/ja307040m. URL info
  • CECIONI, Samy, Sophie FAURE, Ulrich DARBOST, Isabelle BONNAMOUR, Helene PARROT-LOPEZ, Olivier ROY, Claude TAILLEFUMIER, Michaela WIMMEROVÁ, Jean-Pierre PRALY, Anne IMBERTY a Sebastien VIDAL. Selectivity among Two Lectins: Probing the Effect of Topology, Multivalency and Flexibility of “Clicked” Multivalent Glycoclusters. Chemistry - A European Journal. WILEY-VCH, 2011, roč. 17, č. 7, s. 2146–2159. ISSN 0947-6539. Dostupné z: https://dx.doi.org/10.1002/chem.201002635. info
  • GILBOA-GARBER, Nechama, Keren D. ZINGER-YOSOVICH, Dvora SUDAKEVITZ, Batya LERRER, Anne IMBERTY, Michaela WIMMEROVÁ, Albert M. WU a Nachman GARBER. The Five Bacterial Lectins: PA-IL, PA-IIL, RSL, RS-IIL and CV-IIL Interactions with Diverse Animal Cells and Glycoproteins. In The Molecular Immunology of Complex Carbohydrates-3. New York: Springer Science+Business Media, LLC, 2011, s. 155-212, 57 s. Advances in Experimental Medicine and Biology, 705. ISBN 978-1-4419-7876-9. info
  • ŠULÁK, Ondřej, Gianluca CIOCI, Emilie LAMEIGNÈRE, Viviane BALLOY, Adam ROUND, Irina GUTSCHE, Lenka MALINOVSKÁ, Michel CHIGNARD, Paul KOSMA, Daniel F AUBERT, Cristina L MAROLDA, Miguel A VALVANO, Michaela WIMMEROVÁ a Anne IMBERTY. Burkholderia cenocepacia BC2L-C Is a Super Lectin with Dual Specificity and Proinflammatory Activity. PLoS Pathogens. PUBLIC LIBRARY SCIENCE, 2011, roč. 7, č. 9, s. "nestránkováno", 14 s. ISSN 1553-7366. Dostupné z: https://dx.doi.org/10.1371/journal.ppat.1002238. URL info
  • ŠULÁK, Ondřej, Gianluca CIOCI, Monia DELIA, Martina LAHMANN, Annabelle VARROT, Anne IMBERTY a Michaela WIMMEROVÁ. A TNF-like Trimeric Lectin Domain from Burkholderia cenocepacia with Specificity for Fucosylated Human Histo-Blood Group Antigens. Structure. CAMBRIDGE: CELL PRESS, 2010, roč. 18, č. 1, s. 59-72. ISSN 0969-2126. Dostupné z: https://dx.doi.org/10.1016/j.str.2009.10.021. URL info
  • LAMEIGNERE, Emilie, Tze Chieh SHIAO, Rene ROY, Michaela WIMMEROVÁ, Fréderic DUBREUIL, Annabelle VARROT a Anne IMBERTY. Structural basis of the affinity for oligomannosides and analogs displayed by BC2L-A, a Burkholderia cenocepacia soluble lectin. Glycobiology. Oxford: Oxford University Press, 2010, roč. 20, č. 1, s. 87-98. ISSN 0959-6658. Dostupné z: https://dx.doi.org/10.1093/glycob/cwp151. info
  • WIMMEROVÁ, Michaela, Navnit Kumar MISHRA, Martina POKORNÁ a Jaroslav KOČA. Importance of oligomerisation on Pseudomonas aeruginosa Lectin-II binding affinity. In silico and in vitro mutagenesis. Journal of Molecular Modeling. 2009, roč. 15, č. 6, s. 673-679. ISSN 1610-2940. info
  • ŠULÁK, Ondřej, Emile LAMEIGNERE, Michaela WIMMEROVÁ a Anne IMBERTY. Specificity and affinity studies in lectin/ carbohydrate interactions. Online. In Carbohydrate Chemistry. 35. vyd. UK: The Royal Society of Chemistry 2009, 2009, s. 356-371. SPR Carbohydrate Chemistry, Vol. 35. ISBN 978-1-84755-880-0. Dostupné z: https://dx.doi.org/10.1039/b901572h. info
  • HANSEN, Sara, Emmanuel BETTLER, Michaela WIMMEROVÁ, Anne IMBERTY, Olivier LEROUXEL a Christelle BRETON. Combination of several bioinformatics approaches for the identification of new putative glycosyltransferases in Arabidopsis. Journal of Proteome Research. Washington, USA: ACS, 2009, roč. 8, č. 2, s. 743-753. ISSN 1535-3893. info
  • CHEMANI, Chanez, Anne IMBERTY, Sophie DE BENTZMANN, Maud PIERRE, Michaela WIMMEROVÁ, Benoit P. GUERY a Karine FAURE. Role of LecA and LecB Lectins in Pseudomonas aeruginosa-Induced Lung Injury and Effect of Carbohydrate Ligands. INFECTION AND IMMUNITY. The American Society for Microbiology, 2009, roč. 77, č. 5, s. 2065-2075. ISSN 0019-9567. info
  • TESAŘÍK, Radek, Vojtěch SEDLÁČEK, Jana PLOCKOVÁ, Michaela WIMMEROVÁ, Jaroslav TURÁNEK a Igor KUČERA. Heterologous expression and molecular characterization of the NAD(P)H:acceptor oxidoreductase (FerB) of Paracoccus denitrificans. Protein Expression and Purification. Elsevier, 2009, roč. 68, č. 2, s. 233-238. ISSN 1046-5928. info
  • ADAM, Jan, Zdeněk KŘÍŽ, Martin PROKOP, Michaela WIMMEROVÁ a Jaroslav KOČA. In silico mutagenesis and docking studies of Pseudomonas aeruginosa lectin PA-IIL - predicting binding modes and energies. Journal of Chemical Information and Modeling. 2008, roč. 48, č. 11, s. 2234-2242, 8 s. ISSN 1549-9596. info
  • BLANCHARD, Bertrand, Alessandra NURISSO, Emilie HOLLWILLE, Cecile TETAUD, Joele WIELLS, Martina POKORNÁ, Michaela WIMMEROVÁ, Annabelle VARROTTE a Anne IMBERTY. Structural Basis of the Preferential Binding for Globo-Series Glycosphingolipids Displayed by Pseudomonas aeruginosa Lectin I. Journal of Molecular Biology. Amsterdam: Elsevier, 2008, roč. 383, č. 4, s. 837-853. ISSN 0022-2836. info
  • KIRKEBY, Svend, Michaela WIMMEROVÁ, Dennis MOE a Axel K. HANSEN. The mink as an animal model for Pseudomonas aeruginosa adhesion: binding of the bacterial lectins (PA-IL and PA-IIL) to neoglycoproteins and to sections of pancreas and lung tissues from healthy mink. Microbes and Infection. Paris: Elsevier, 2007, roč. 9, č. 5, s. 566-573. ISSN 1286-4579. info
  • ADAM, Jan, Martina POKORNÁ, Charles SABIN, Edward P. MITCHELL, Anne IMBERTY a Michaela WIMMEROVÁ. Engineering of PA-IIL lectin from Pseudomonas aeruginosa - Unravelling the role of the specificity loop for sugar preference. BMC Structural Biology. 2007, roč. 7, č. 36, s. 1-13. ISSN 1472-6807. info
  • MARROTE, Karine, Charles SABIN, Cathy PRÉVILLE, Myriam MOUMÉ-PYMBOCK, Michaela WIMMEROVÁ, Edward P. MITCHELL, Anne IMBERTY a René ROY. X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives. ChemMedChem. Weinheim: WILEY-VCH Verlag GmbH & Co. KGaA, 2007, roč. 2, č. 9, s. 1328-1338. ISSN 1860-7187. info
  • WIMMEROVÁ, Michaela, Emilie LAMEIGNERE, Lenka MALINOVSKÁ, Charles SABIN, Jan ADAM, Martina POKORNÁ, Annabelle VARROT, Edward P. MITCHELL a Anne IMBERTY. High affinity lectins from human opportunistic pathogens: structure/function studies. In XIX International Symposium on Glycoconjugates. Cairns, Australie: IGO, 2007, s. 56-56. info
  • SABIN, Charles, Edward P. MITCHELL, Martina POKORNÁ, Catherine GAUTIER, J. UTILE, Michaela WIMMEROVÁ a Anne IMBERTY. Binding of different monosaccharides by lectin PA-IIL from Pseudomonas aeruginosa: Thermodynamics data correlated with X-ray structures. FEBS Letters. Amsterdam: Elsevier Science B.V., 2006, roč. 580, č. 2, s. 982-987. ISSN 0014-5793. info
  • POKORNÁ, Martina, Gianluca CIOCCI, Stephanie PERRET, Etienne REBUFFET, Nikola KOSTLÁNOVÁ, Jan ADAM, Nechama GILBOA-GARBER, Edward P. MITCHELL, Anne IMBERTY a Michaela WIMMEROVÁ. Unusual Entropy Driven Affinity of Chromobacterium violaceum Lectin CV-IIL towards Fucose and Mannose. Biochemistry. USA: American Chemical Society, 2006, roč. 45, č. 24, s. 7501-7510. ISSN 0006-2960. info
  • IMBERTY, Anne, Michaela WIMMEROVÁ, Charles SABIN a Edward P. MITCHELL. Structures and Roles of Pseudomonas aeruginosa Lectins. In Protein-carbohydrate interactions in infectious diseases. VB: RSC Publishing, 2006, s. 30-48. RSC Biomolecular Sciences Series. ISBN 0-85404-802-2. info
  • IMBERTY, Anne, Michaela WIMMEROVÁ, Jaroslav KOČA a Christelle BRETON. Molecular modelling of glycosyltransferases. In Glycobiology Protocols. Totowa: Humana Press Inc., 2006, s. 145-156. Methods in Molecular Biology, Vol. 347. ISBN 1-58829-553-2. info
  • MITCHELL, Edward, Charles SABIN, Lenka ŠNAJDROVÁ, Martina POKORNÁ, Stephanie PERRET, Catherine GAUTIER, Ctirad HOFR, Nechama GILBOA-GARBER, Jaroslav KOČA, Michaela WIMMEROVÁ a Anne IMBERTY. High affinity fucose binding of Pseudomonas aeruginosa lectin PA-IIL: 1.0 A resolution crystal structure of the complex combined with thermodynamics and computational chemistry approaches. Proteins: Structure, Function, and Bioinformatics. Wiley, 2005, roč. 58, č. 3, s. 735-746. ISSN 0887-3585. info
  • KOSTLÁNOVÁ, Nikola, Edward MITCHELL, Hugues LORTAT-JACOB, Stefan OSCARSON, Martina LAHMANN, Nechama GILBOA-GARBER, Gerard CHAMBAT, Michaela WIMMEROVÁ a Anne IMBERTY. The fucose-binding lectin from Ralstonia solanacearum: a new type of beta-propeller architecture formed by oligomerisation and interacting with fucoside, fucosyllactose and plant xyloglucan. Journal of Biological Chemistry. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., 2005, roč. 280, č. 30, s. 27839-27849. ISSN 0021-9258. info
  • PERRET, Stephanie, Charles SABIN, Claire DUMON, Martina POKORNÁ, Catherine GAUTIER, Oxana GALANINA, Shahov ILIA, Nicolai BOVIN, Magali NICAISE, Michel DESMADRIL, Nechama GILBOA-GARBER, Michaela WIMMEROVÁ, Edward P. MITCHELL a Anne IMBERTY. Structural basis for the interaction between human milk oligosaccharides and a bacterial protein, Pseudomonas aeruginosa lectin PA-IIL,. Biochemical Journal. 2005, roč. 389, č. 2, s. 325-332. ISSN 0264-6021. info
  • IMBERTY, Anne, Edward P. MITCHELL a Michaela WIMMEROVÁ. Structural basis of high-affinity glycan recognition by bacterial and fungal lectins. Current Opinion in Structural Biology. London: Elsevier Science Ltd., 2005, roč. 15, č. 5, s. 525-534, 11 s. ISSN 0959-440X. info
  • IMBERTY, Anne, Michaela WIMMEROVÁ, Edward P. MITCHELL a Nechama GILBOA-GARBER. Structures of the lectins from Pseudomonas aeruginosa: Insights into molecular basis for host glycan recognition. Microbes and Infection. Paris: Elsevier, 2004, roč. 6, č. 2, s. 221-228. ISSN 1286-4579. info
  • SUDAKEVITZ, Dvora, Nikola KOSTLÁNOVÁ, Gittit BLATMAN-JAN, Edward P. MITCHELL, Batia LERRER, Michaela WIMMEROVÁ, Don J. KATCOFF, Anne IMBERTY a Nechama GILBOA-GARBER. A new Ralstonia solanacearum high affinity mannose-binding lectin. Molecular Microbiology. Blackwell Publishing Ltd, 2004, roč. 52, č. 3, s. 691-700. ISSN 0950-382X. info
  • JANICZEK, Oldřich, Zdeněk GLATZ, Michaela WIMMEROVÁ a Jitka PSOTOVÁ. Purification and some properties of isocitrate dehydrogenase from Paracoccus denitrificans. Preparative Biochemistry. New York: Marcel Dekker, Inc., 2004, roč. 34, č. 3, s. 279-289, 10 s. ISSN 0032-7484. info
  • WIMMEROVÁ, Michaela, Edward MITCHELL, Jean-Frederick SANCHEZ, Catherine GAUTIER a Anne IMBERTY. Six-bladed ß -propeller fold and novel fucose recognition mode for Aleuria aurantia lectin. Journal of Biological Chemistry. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., 2003, roč. 278, č. 29, s. 27059-27067, 8 s. ISSN 0021-9258. info
  • WIMMEROVÁ, Michaela, Soren B. ENGELSEN, Emmanuel BETTLER, Christelle BRETON a Anne IMBERTY. Combining fold recognition and exploratory data analysis for searching for glycosyltransferases in the genome of Mycobacterium tuberculosis. Biochimie. Elsevier, 2003, roč. 85, č. 7, s. 691-700. ISSN 0300-9084. info
  • CIOCCI, Gianluca, Edward MITCHELL, Catherine GAUIER, Michaela WIMMEROVÁ, Dvora SUDAKEVITZ, Serge PÉREZ, Nechama GILBOA-GARBER a Anne IMBERTY. Structural basis of calcium and galactose recognition by the lectin PA IL of Pseudomonas aeruginosa. FEBS Letters. Amsterdam: Elsevier, 2003, roč. 552, č. 2, s. 297-301. ISSN 0014-5793. info
  • MITCHELL, Edward, Corinne HOULES, Dvora SUDAKEVITZ, Michaela WIMMEROVÁ, Catherine GAUTIER, Serge PÉREZ, Albert M. WU, Nechama GILBOA-GARBER a Anne IMBERTY. Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients. Nature Structural Biology. New York: Nature America Inc., 2002, roč. 9, č. 12, s. 918-921. ISSN 1072-8368. info
  • MARVANOVÁ, Soňa, Yuji NAGATA, Michaela WIMMEROVÁ, Jana SÝKOROVÁ, Kamila HYNKOVÁ a Jiří DAMBORSKÝ. Biochemical characterization of broad-specificity enzymes using multivariate experimental design and a colorimetric microplate assay: characterization of the haloalkane dehalogenase mutants. Journal of Microbiological Methods. 2001, roč. 44, č. 1, s. 149-157. ISSN 0167-7012. URL info
  • GLATZ, Zdeněk, María Victoria MARINI PALOMEQUE, Michaela WIMMEROVÁ, Jiří DAMBORSKÝ a Yuji NAGATA. Determination of haloalkane dehalogenase enzymatic activity by capillary zone electrophoresis. Journal of Chromatography A. Netherlands: Elsevier, 2000, roč. 895, 1-2, s. 219-225. ISSN 0021-9606. URL info
  • GLATZ, Zdeněk, María Victoria MARINI PALOMEQUE, Michaela WIMMEROVÁ, Jiří DAMBORSKÝ a Yuji NAGATA. Rapid detection of haloalkane dehalogenase activity by capillary zone electrophoresis. Chemické Listy. Praha: Česká společnost chemická, 2000, roč. 94, č. 8, s. 588-589. ISSN 0009-2770. info
  • SÝKOROVÁ, Jana, Michaela WIMMEROVÁ, Jiří DAMBORSKÝ a Yuji NAGATA. Purification, crystallization and kinetic characterization of g-hexachlorocyclohexane dehydrochlorinase from sphingomonas paucimobilis ut26. Chemiské listy. Praha: Česká společnost chemická, 2000, roč. 94, č. 8, s. 574. ISSN 0009-2770. info
  • WIMMEROVÁ, Michaela a Lumír MACHOLÁN. Sensitive amperometric biosensor for the determination of biogenic and synthetic amines using pea seedling amine oxidase: a novel approach for enzyme immobilisation. Biosensors & Bioelectronics. Oxford: Elsevier Advanced Technology, 1999, roč. 14, 8-9, s. 695-702. ISSN 0956-5663. info
  • WIMMEROVÁ, Michaela, Lumír MACHOLÁN a Vladimír PROCHÁZKA. Enzyme biosensor for plasma histamine assay. Chemical Papers. Bratislava: Slovak Academic Press, 1998, roč. 52, s. 794-795. ISSN 0366-6352. info
  • ŠEBELA, Marek, Marie STUDNIČKOVÁ a Michaela WIMMEROVÁ. Differential pulse polarographic study of the redox centres in pea amine oxidase. Bioelectrochemistry and Bioenergetics. Lausanne: Elsevier Sequoia S.A., 1996, roč. 41, s. 173-179. ISSN 0302-4598. info
  • GLATZ, Zdeněk, Oldřich JANICZEK a Michaela WIMMEROVÁ. Detection of quinoproteins after electrophoresis in the presence of urea or SDS. Biochem. Mol. Biol. Int. Academic Press, 1995, roč. 35, č. 1, s. 1-10. ISSN 1039-9712. info
  • WIMMEROVÁ, Michaela, Zdeněk GLATZ a Oldřich JANICZEK. Improved chromatographic purification of pea seedlings diamine oxidase. Preparative Biochemistry. New York: Marcel Dekker, Inc., 1993, roč. 23, č. 3, s. 303-319. ISSN 0032-7484. info
  • ŽÍDEK, Lukáš a Michaela WIMMEROVÁ. Osnova paradigmat biochemie? Chemické listy. Praha: Česká společnost chemická, 1993, roč. 87, č. 1, s. 122-125. ISSN 0009-2770. info

2017/08/21

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