Project information
New trends in electrochemistry of nucleic acids and their applications in enviromental chemistry
- Project Identification
- GA203/02/0422
- Project Period
- 1/2002 - 12/2004
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
- Cooperating Organization
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Institute of Biophysics
- Responsible person RNDr. František Jelen, CSc.
Electrochemical methods represent fast and inexpensive approach in studies of structure, interactions and properties of biomacromolecules. In this project modem electrochemical techniques will be applied in connection with mercury and solid electrodes to study oligonucleotides and nucleic acids and then-interactions with some drugs and carcinogens. Information on the adsorption and redox properties of oligonucleotides with respect to their nucleotide sequences and lengths will be obtained. Electrochemica studies will concentrate also on interaction of the nucleic acids strands at the electrode surface aimed for developing sensors for various kind of nucleic acid damage and detection of genotoxic compounds in environment.
Publications
Total number of publications: 57
2002
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Elimination Voltammetry of Nucleic Acids on Silver Electrodes
Bioelectrochemistry, year: 2002, volume: 2002, edition: 55
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Partial least squares and artificial neural networks for multicomponent analysis from derivative UV-Vis spectra
International Chemometric Conference - CHEMOMETRICS VI, year: 2002
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Přednosti eliminační voltametrie
Moderní polarografické/voltametrické metody analýzy vod a vodných roztoků, Sborník přednášek z celostátního semináře, year: 2002
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Rozlišení signálů adeninu a cytosinu v oligonukleotidech pomocí eliminační voltametrie
Sborník přednášek z XXII.celostátního semináře, year: 2002
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Use of artificial neural networks for the evaluation UV-Vis spectra of adenine and cytosine in mixtures
Chemické listy, year: 2002
2000
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Elektrochemická studie DNA na pevných elektrodách
Biochemie a molekulární biologie na prahu nového tisíciletí, year: 2000
1993
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Application of Elimination Polarography to the Study of Electrode Processes
J.Electroanal.Chem., year: 1993, volume: 1993, edition: 348