Project information
Analysis of biologically important molecular complexes
- Project Identification
- VS97032
- Project Period
- 9/1997 - 12/2000
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Support to University Research Programmes
- MU Faculty or unit
- Faculty of Science
- Keywords
- biomacromolecules; nucleoprotein complexes; chromatin structure; chromosome architecture; telomeres
The aim of the project is to build a laboratory focused on the study of functionally important complexes of biomacromolecules, namely those of nucleic acids and proteins, which form so called genome architecture (telomeres, centromeres, A study of the genetic heterochromatin blocks, complexes of nuclear matrix, nucleosomes). Metabolism of genetic material (replication, transcription, recombination) proceeds at these complexes and is, therefore, significantly affectedby their properties. information in its nuclear context will determine the basis of education of our postgraduate students. During the next four years, the nucleoprotein complexes will be characterised, which form indispensable functional elements of eukaryotic chromosomes - the telomeres.
Publications
Total number of publications: 34
2000
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The Health Industry Council
Year: 2000, edition: Vyd. 1, number of pages: 12 s.
1999
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An in Situ Study of Variant Telomeric Repeats in Human Chromosomes
Genomics, year: 1999, volume: 58, edition: 2
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Dissection of homologous recombination
Embo Workshop Functional Organization of the Cell Nucleus, year: 1999
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In situ studies of human telomeres
Abstracts of the Second European Cytogenetics Conference, year: 1999
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Molecular Cytogenetics Investigation of The Telomers in a Case of Philadelphia Positive B-ALL with a Single Telomere Expansion
Neoplasia, year: 1999, volume: 1, edition: 6
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Molecular Dissection of Homologous Recombination
The Meiotic Process: Nuclear Architecture, Recombination and Chromosomal Segregation, year: 1999
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P80/ detailní mapování methylcystosinů v oblasti Pa promotoru BCR-ABL lokusu u pacientů s diagnózou CML a dvou modelových buněčných linií, K562 a BV173
Sborník abstrakt, year: 1999
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Sledování aktivity telomerázy v průběhu léčby dětských leukémií
Sborník abstrakt, year: 1999
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Targeted deletions created in yeast vectors by recombinational excision
Nucletic Acids Research, year: 1999, volume: 27, edition: 8
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TAS49-a dispersed repetitive sequence isolated from subtelomeric regions of Nicotiana tomentosiformis chromosomes
Genome, year: 1999, volume: 43, edition: 2