Project information
European Human Biomonitoring Initiative
(HBM4EU)
- Project Identification
- 733032
- Project Period
- 1/2017 - 6/2022
- Investor / Pogramme / Project type
-
European Union
- Horizon 2020
- Health, demographic change and wellbeing (Societal Challenges)
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jana Klánová, Ph.D.
- Mgr. Ondřej Adamovský, Ph.D.
- Lola Murielle Bajard ép.Esner, Ph.D.
- prof. RNDr. Luděk Bláha, Ph.D.
- doc. RNDr. Pavel Čupr, Ph.D.
- Elena Dominguez Romero, PhD.
- Mgr. Klára Komprdová, Ph.D.
- Ing. Štěpán Koudelka, Ph.D.
- RNDr. Ondřej Májek, Ph.D.
- Lisa Emily Melymuk, Ph.D.
- Chander Kant Negi, Ph.D.
- Mgr. Ondřej Ngo, Ph.D.
- Ing. Šárka Palátová, Ph.D.
- Veronika Janina Schacht, Ph.D.
- Mgr. Libor Šulc, Ph.D.
- Jakub Vinkler, DiS.
- Chiara Maria Vitale, PhD
- Cooperating Organization
-
Institute of Experimental Medicine of the ASCR, v. v. i.
- Responsible person MUDr. Radim Šrám, DrSc.
- Responsible person prof. MUDr. Milena Králíčková, Ph.D.
- Responsible person prof. Ing. Jana Hajšlová, CSc.
- Responsible person Ing. Adéla Fraňková, Ph.D.
- Responsible person Gorazd B. Stokin
- Responsible person RNDr. Ondřej Májek, Ph.D.
- Responsible person Marike Kolossa-Gehring
The overarching goal of the European Human Biomonitoring Initiative is to generate knowledge to inform the safe management of chemicals and so protect human health. We will use human biomonitoring to understand human exposure to chemicals and resulting health impacts and will communicate with policy makers to ensure that our results are exploited in the design of new chemicals policies and the evaluation of existing measures.
Key objectives include:
- Harmonizing procedures for human biomonitoring across 26 countries, to provide policy makers with comparable data on human internal exposure to chemicals and mixtures of chemicals at EU level;
- Linking data on internal exposure to chemicals to aggregate external exposure and identifying exposure pathways and upstream sources. Information on exposure pathways is critical to the design of targeted policy measures to reduce exposure;
- Generating scientific evidence on the causal links between human exposure to chemicals and negative health outcomes; and
- Adapting chemical risk assessment methodologies to use human biomonitoring data and account for the contribution of multiple external exposure pathways to the total chemical body burden.
We will achieve these objectives by harmonizing human biomonitoring initiatives in 26 countries, drawing on existing expertise and building new capacities. By establishing National Hubs in each country to coordinate activities, we will create a robust Human Biomonitoring Platform at European level. This initiative contributes directly to the improvement of health and well-being for all age groups, by investigating how exposure to chemicals affects the health of different groups, such as children, pregnant women, foetuses and workers. We will also investigate how factor such as behavior, lifestyle and socio-economic status influence internal exposure to chemicals across the EU population. This knowledge will support policy action to reduce chemical exposure and protect
health.
Publications
Total number of publications: 51
2022
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AOP-helpFinder webserver: a tool for comprehensive analysis of the literature to support adverse outcome pathways development
Bioinformatics, year: 2022, volume: 38, edition: 4, DOI
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Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study
International Journal of Environmental Research and Public Health, year: 2022, volume: 19, edition: 21, DOI
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Cadmium exposure in adults across Europe: Results from the HBM4EU Studies 2014-2020
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, year: 2022, volume: 246, edition: September 2022, DOI
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Critical review of analytical methods for the determination of flame retardants in human matrices
Analytica Chimica Acta, year: 2022, volume: 1193, edition: February 2022, DOI
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Cumulative risk assessment of five phthalates in European children and adolescents
International Journal of Hygiene and Environmental Health, year: 2022, volume: 246, edition: September 2022, DOI
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Current Advances, Research Needs and Gaps in Mycotoxins Biomonitoring under the HBM4EU-Lessons Learned and Future Trends
Toxins, year: 2022, volume: 14, edition: 12, DOI
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Enhancing Human Biomonitoring Studies through Linkage to Administrative Registers-Status in Europe
International Journal of Environmental Research and Public Health, year: 2022, volume: 19, edition: 9, DOI
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Harmonization of Human Biomonitoring Studies in Europe: Characteristics of the HBM4EU-Aligned Studies Participants
International Journal of Environmental Research and Public Health, year: 2022, volume: 19, edition: 11, DOI
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Harmonized Quality Assurance/Quality Control Provisions for Nontargeted Measurement of Urinary Pesticide Biomarkers in the HBM4EU Multisite SPECIMEn Study
Analytical chemistry, year: 2022, volume: 94, edition: 22, DOI
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LC-HRMS based method for suspect/non-targeted screening for biomarkers of chemical exposure in human urine
Chemosphere, year: 2022, volume: 300, edition: August 2022, DOI