prof. Mgr. Petr Beneš, Ph.D.
Consultant
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Doctoral degree in full-time or combined form. The language of instruction is Czech.
The programme can be studied only as a single subject.
The program is product of fusion of former independent Molecular and Cellular Biology with General and Molecular Genetics. We propose the fusion to reflect modern holistic approaches dominating in both fields that converge them to close proximity and bringing benefits to both of them. The aim of the program is providing excellent scientific education in the field of molecular and cell biology and genetics. The graduates thus should be proficient to accomplish research of living phenomena on molecular, cellular, tissue or organismal levels. To achieve this aim, students are systematically guided to advance their theoretical knowledge in the field and master practical skills in applications of modern methods of molecular and cellular biology, genetics and other related fields. The key themes include study of genes and genomes and their expression in microorganisms, plants, animals and humans. Special attention is paid to their relations to pathological conditions. Research performed on microorganisms is focused preferentially on molecular diagnosis and genomics of selected pathogenic and clinically significant bacterial strains and their interactions with bacteriophages. Research of plants is concentrated mainly on genes of model plants and plants used in agriculture. In animals and humans, research is focused on genetical structure of populations, molecular diagnosis of prenatal and postnatal pathogenic situations, genetics of tumors, study of signalling processes connected with deregulation of proliferation, differentiation and programmed cell death in tumor cells and detection of genetical factors associated with certain polygenic diseases. Students are free to perform independent research in well-equipped laboratories and experienced supervisors are nominated to guide them in this effort. Students are continuously confronted with progress in the field by discussions in regular laboratory meetings, institutional seminars or conferences. Students successfully presenting their results in conferences or written articles can be awarded by special scholarships for excellent representation of the Deparmtent of Experimental Biology and following activities:
1. Successfull presentation record resulting from reaching aims of Ph.D. thesis projects, such as:
The scholarship can be used for partial covering of travel/accomodation expenses or conference fees.
The essential condition for awarding the scholarship is correct affiliation of the presentations (both papers and conference abstracts) to the Deparment of Experimental Biology, Faculty of Science, Masaryk University.
2. Participation in teaching younger students of Master programmes how to perform experimental methods and interprete the results obtained.
3. Participation in grant projects. Long-lasting participation and significant contribution to accomplishing the projects aims can be awarded by getting part-time job or contract for certain period.
“Windows of the living cell universe wide-opened.”
The students who are interested in applied research can collaborate with companies as Repromeda (assisted reproduction), MB Pharma (devising phage preparations) or to participate in grant projects funded by TACR leading to applied outcomes. We aim to further support contractual research with applied potential, search for suitable partners and provide them with option to collaborate with students interested in this kind of research.
Additional information can be found in following addresses:
http://www.sci.muni.cz/cz/DoktorskeStudium/Prehled-programu-a-oboru
http://www.sci.muni.cz/cz/UEB
The Office for Doctoral Studies, Quality, Academic Affairs and Internationalization takes care of doctoral students SCI MU
https://www.sci.muni.cz/en/students/phd
On the department's website, you can find the following information:
but also office hours, contacts, news, information on skills development and scholarships.
Detailed information on stays abroad can be found on this website:
https://www.sci.muni.cz/en/students/phd/develop-your-skills/stay-abroad
Graduates find positions in various research institutes, universities, hospitals and other medical facilities and laboratories oriented to virology, microbiology, genetics, biochemistry, immunology, pharmacology, pathology, etc. They are ready to perform independent research, draft scientific projects, create grant applications, design experimental work itself, interprete results rigorously and present them in oral as well as written forms. They are also educated to act as teachers. Graduates from this program are sought-after by employers and many of them currently work on positions of leading researchers, university teachers, top managers and directors in various research and education institutions in Brno, Prague, Ostrava, České Budějovice, Olomouc, etc. Many graduates leaves for postdoctoral stays abroad, especially to west-european countries, USA, Canada, Japan, Australia. They often become highly-appreciated members of research teams there.
Data from the previous admission procedure (2 Jan – 15 Dec 2024)
More information about admission process for international applicants in general can be found in the section Admission Process.
Date of the entrance exam
The applicants will receive information about the entrance exam by e-mail usually at least 10 days before the exam.
Please, always check your e-mails, including spam folders.
Conditions of admission
To be admitted, a candidate must obtain a total of 70 out of 100 points in the expert knowledge part and 60 out of 100 points in the language part.
Successful applicants are informed of their acceptance by e-mail and subsequently receive an invitation to the enrolment.
Programme capacity
The capacity of a given programme is not fixed; students are admitted based on a decision by the Doctoral Board after assessing their aptitude for study and motivation.
Neuroblastoma is the most common and highly lethal extracranial pediatric solid tumor, characterized by extensive intratumor and interpatient heterogeneity that dictates its clinical manifestation and complicates its management. Currently, about one in ten low- and intermediate-risk patients is misclassified and eventually dies from progressive disease, while available therapies still fail in half of the high-risk neuroblastoma cases. Neuroblastoma arises anywhere along the sympathetic nervous system, probably from neural crest cell (NCC)-derived sympathoadrenal progenitors. Recent single-cell transcriptomics studies of our collaborators shed new light on NCC differentiation and provided unprecedented insights into differentiation trajectories and cellular transition states during normal sympathoadrenal development. As suggested by our published and preliminary results, translating this updated understanding of the sympathoadrenal development into neuroblastoma research might hold the key for unraveling neuroblastoma heterogeneity. The main aim of this thesis is to explore the utility of single-cell transcriptomics data for identification of clinically useful therapeutic targets and markers that could be streamlined into improved neuroblastoma treatment protocols.
Supported by the Ministry of Health of the Czech Republic, project NW24-07-00017.
PLEASE NOTE: Before initiating the formal application process to doctoral studies, interested candidates are required to contact Dr. Jan Škoda for informal discussion.
Téma je rezervováno. This topic is reserved.
Provided by | Faculty of Science | |
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Type of studies | Doctoral | |
Mode | full-time | Yes |
combined | Yes | |
distance | No | |
Study options | single-subject studies | Yes |
single-subject studies with specialization | No | |
major/minor studies | No | |
Standard length of studies | 4 years | |
Language of instruction | Czech | |
Collaborating institutions |
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Doctoral board and doctoral committees |
Consultant
e‑mail: |
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