Informace o projektu
iNEXT-Discovery: Infrastructure for transnational access and discovery in integrated structural biology
(iNEXT- Discovery)
- Kód projektu
- 871037
- Období řešení
- 2/2020 - 7/2024
- Investor / Programový rámec / typ projektu
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Evropská unie
- Horizon 2020
- RI Research Infrastructures (Excellent Science)
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
- doc. RNDr. Radovan Fiala, CSc.
- Anirban Ghosh, Ph. D
- Martina Lenarčič Živkovic, PhD.
- Mgr. Jana Moravcová, Ph.D.
- Mgr. Jiří Nováček, Ph.D.
- doc. Mgr. Lukáš Trantírek, Ph.D.
- Spolupracující organizace
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University of Leeds
Centre National de la Recherche Scientifique
Johann Wolfgang Goethe-Universität
Aarhus Universitet
Eötvös Loránd University
Universiteit Leiden
Universidade Nova de Lisboa
Lunds Universitet
Universiteit Utrecht
The Netherlands Cancer Institute
- Odpovědná osoba Anastassis Perrakis
Agencia Estatal Consejo Superior
EATRIS ERIC
Instruct ERIC
Consorzio Interuniversitario Risonanze Magnetich/di Metallo Proteine (C.I.R.M.M.P.)
EU-OPENSCREEN ERIC
EMBL ¨(EUROPEAN MOLECULAR BIOLOGY LABORATORY)
iNEXT-Discovery, a novel infrastructure for NMR, Electron microscopy (EM) and X-rays for Translational research (iNEXT) will enable the Discovery of new pharmaceuticals, biologics, materials, biofuels, food formulations, and other tools that European scientists can envisage, and that we can help to bring to reality. The iNEXT-Discovery builds on the success of iNEXT, taking it further by enabling more efficient and new cutting-edge structural biology access to users, facilitating for instance fragment-based drug discovery campaigns, the structure determination of large molecular machines, the observation of molecular structures and dynamics within cells, and numerous more applications by the wider user community. iNEXT-Discovery aims to fully release the enormous potential of advanced instruments and top-notch scientific expertise from leading European research infrastructures for structural biology, making it available across scientific disciplines and all across Europe. This main objective will be realised by the coordinated offering of access to the existing structural biology community, but crucially also to user communities that have been less exposed to these facilities. The rich and energetic research environment that is available at all partner sites catalyses the four joint research activities within the iNEXT-Discovery project. We aim to further consolidate a strong structural biology presence in drug discovery pipelines by streamlining fragment based drug discovery pipelines, by high-throughput delivery of samples to maximise the efficiency of user access in our facilities, on offering novel scientific opportunities for following molecules in time, and on developing more efficient tools and procedures to analyse structures in situ within cells. All the iNEXT-Discovery JRAs aim to improve structural biology technology. Also, we will embrace a strong focus on the digitalisation and automation of structural biology services. Together, our JRAs will strongly improve the access provision of the offered technologies to facility users, both novice and experienced.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 8
2024
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In-cell NMR suggests that DNA i-motif levels are strongly depleted in living human cells
Nature Communications, rok: 2024, ročník: 15, vydání: 1, DOI
2023
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A thermosensitive gel matrix for bioreactor-assisted in-cell NMR of nucleic acids and proteins
Journal of biomolecular NMR, rok: 2023, ročník: 77, vydání: 5-6, DOI
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Structural basis for different membrane-binding properties of<i> E.</i><i> coli</i> anaerobic and human mitochondrial 8-oxidation trifunctional enzymes
Structure, rok: 2023, ročník: 31, vydání: 7, DOI
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Structural conservation of antibiotic interaction with ribosomes
NATURE STRUCTURAL & MOLECULAR BIOLOGY, rok: 2023, ročník: 30, vydání: 9, DOI
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Structure of the Borrelia Bacteriophage uBB1 Procapsid
Journal of Molecular Biology, rok: 2023, ročník: 435, vydání: 24, DOI
2021
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In-Cell NMR Spectroscopy of Functional Riboswitch Aptamers in Eukaryotic Cells
Angewandte Chemie International Edition, rok: 2021, ročník: 60, vydání: 2, DOI
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Investigation of the structure and dynamics of gallium binding to high-affinity peptides elucidated by multi-scale simulation, quantum chemistry, NMR and ITC dagger
Physical Chemistry Chemical Physics, rok: 2021, ročník: 23, vydání: 14, DOI
2019
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iNEXT workshop on Integrated methodologies and approaches for structural biology
Rok: 2019, druh: Uspořádání workshopu