Project information
Cellular and extracellular environment for the axon regenaration following injury of the spinal roots and peripheral nerves
- Project Identification
- GA309/00/0407
- Project Period
- 1/2000 - 1/2002
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Medicine
In contrast to the CNS environment, the peripheral nerves of mammals provide cellular and extracellular conditions supporting the regeneration of axons. The supporting conditions originate distal to the point of injury during Wallerian degeneration that results in formation of immature Schwann cells. The cells restore the production of molecules which promote axonal regrowth. The synthesis of axon-promoting molecules by Schwann cells and suitable content of their extracellular matrix are important extri nsic factors influencing the axon regeneration in the peripheral nervous systém. Some recent reports suggest that the cellular and extracellular environment is probably not the same for regeneration of motor and somatosensory axons in the peripheral ner ves. In addition, formation of different extrinsic cues supporting the axonal regeneration of the motor and somatosensory axons in the damaged peripheral nerves as well as the ventral and dorsal spinal roots of the rats. The spatial-temporal changes of t
Publications
Total number of publications: 26
2000
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IMMUNOHISTOCHEMICAL DIFFERENCES IN THE ECM CONTENT ALONGSIDE AFFERENT AND MOTOR AXONS IN RELATION TO THE POSITION OF THE DORSAL ROOT GANGLION
37th Proceedings of Czech Society of Histochemistry and Cytochemistry, year: 2000
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Immunohistochemical study of proliferation and apoptosis in the dorsal root ganglia after supraspinal and infraspinal axotomy.
Sborník lékařský, year: 2000
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Migrating Schwann cells support the endoneurium of acellular nerve segment by laminins, fibronectin, thrombospondin, and chondroitin sulfate
Revista de Neurología, year: 2000, volume: 28, edition: 1
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Migrating Schwann cells support the endoneurium of freeze-treated nerve segment by laminins, fibronectin, thrombospondin, and chondroitin sulfate.
Sborník lékařský, year: 2000
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Reinnervation of the rat biceps brachii muscle through the cellular and acellular nerve grafts introduced into the ventral horn of the spinal cord
The AANS-CNS Book, year: 2000
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Schwann cells migrating in absence of the axons in the basal lamina tubes express immunoreactivity for laminins, fibronectin, thrombospondin, and chondroitin sulfate
Eur. J. Neurosci., year: 2000, volume: 12, edition: Suppl. 11