Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1209
2006
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Isolation and characterization of a novel semi-lethal Arabidopsis thaliana mutant of gene for pentatricopeptide (PPR) repeat-containing protein
Genetica, year: 2006, volume: 128, edition: 1-3
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Isolation of Borrelia afzelii from overwintering Culex pipiens biotype molestus mosquitoes
Annals of Agricultural and Environmental Medicine, year: 2006, volume: 13, edition: 2
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Isolation of microbial DNA by newly designed magnetic particles
Colloids and Surfaces B: Biointerferences, year: 2006, volume: 52, edition: 2
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Jun: the master regulator in healthy and cancer cells
Journal of Applied Biomedicine, year: 2006, volume: 4, edition: 4
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Komparativní genomika patogenních kmenů T. pallidum.
X. Pracovní setkání biochemiků a molekulárních biologů. Sborník příspěvků., year: 2006
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Komparativní genomika patogenních kmenů T. pallidum.
Year: 2006, type: Conference abstract
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Komparativní genomová sekvenace (CGS) kmenů rodu Treponema.
Year: 2006, type: Conference abstract
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Komparativní genomová sekvenace (CGS): nový typ sekvenování bakteriálních genomů.
X. Pracovní setkání biochemiků a molekulárních biologů. Sborník příspěvků., year: 2006
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MAPPING AND IDENTIFICATION OF RESISTANCE GENES AGAINST POWDERY MILDEW IN NEW ACCESSIONS OF HORDEUM VULGARE ssp. SPONTANEUM AND PROSPECTS OF OUR FUTURE WORK
Biotechnology 2006, 15.-16.2. České Budějovice, year: 2006
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Mikrokalorimetrie bilogicky významných molekul
Československý časopis pro fyziku, year: 2006, volume: 56, edition: 5