Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1209
2006
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Nestin as a marker of transformed cells in brain tumors.
Year: 2006, type: Conference abstract
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Nestin expression in the cell lines derived from glioblastoma multiforme.
BMC Cancer, year: 2006, volume: 6, edition: 32
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New findings of minority benzo[c]phenenthridine alkaloids
Book of abstracts of CHEMISTRY, PHARMACOLOGY AND BIOSYNTHESIS OF ALKALOIDS, year: 2006
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New Perspectives in the Treatment of Inherited Neuromuscular Disorders: Innovative Ideas for the Third Millenium
Focus on Birth Defects Research, edition: Vyd. 1., year: 2006, number of pages: 24 s.
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O polidštění rostlinných telomer
Vesmír, year: 2006, volume: 85, edition: 136
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Obvyklé a neobvyklé telomery
Informační listy, year: 2006, volume: Neuveden, edition: 30
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Occurance of <I>Staphylococcus nepalensis</I> strains in different sources including human clinical material
FEMS Microbiology Letters, year: 2006, volume: 263, edition: 2
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Okadaická kyselina indukuje diferenciaci a apoptózu monoblastů BM2
X. pracovní setkání biochemiků a molekulárních biologů, year: 2006
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On his anniversary. Gregor Johann Mendel (1822-1884)
On his anniversary. Gregor Johann Mendel (1822-1884), year: 2006
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Optimalizace izolace bakteriální DNA amplifikovatelné v PCR
X. Pracovní setkání biochemiků a molekulárních biologů, year: 2006