Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1209
2006
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Procentuální zastoupení neznámých spirochet a patogenních borrelií v larvách komárů
Year: 2006, type: Conference abstract
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Protein Modification Degree - An Indirect MS Quantitation Approach.
Year: 2006, type: Conference abstract
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Proteom polyvalentního stafylokokového bakteriofága
X. Pracovní setkání biochemiků a molekulárních biologů, year: 2006
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Proteom polyvalentního stafylokokového bakteriofága 812
Študentská vedecká konferencia 2006. Zborník recenzovaných príspevkov - biologická a environmentálna sekcia, year: 2006
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Proteomic and bioinformatic analysis of iron- and sulfur-oxidizing Acidithiobacillus ferrooxidans using immobilized pH gradients and mass spectrometry
Proteomics, year: 2006, volume: 6, edition: 15
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Proteomic characterization of the polyvalent staphylophage 812
Year: 2006, type: Conference abstract
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První zkušenosti s metodou fluorescenční in situ hybridizace při detekci uroteliálního karcinomu.
XXX. Brněnské onkologické dny, year: 2006
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Pseudomonas moraviensis sp. nov. and Pseudomonas vranovensis sp. nov., soil bacteria isolated on nitroaromatic compounds, and emended description of Pseudomonas asplenii
International Journal of Systematic and Evolutionary Microbiology, year: 2006, volume: 56/2006, edition: 11
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Reaktivace proteinu p53 pomocí Amifostinu - experimentální studie v kvasinkovém expresním systému
ABSTRAKTA, year: 2006
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Recognition of pore-forming colicin Y by its cognate immunity protein.
FEMS Microbiology Letters, year: 2006, volume: 258, edition: 1