Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1209
2006
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p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts
ISREC conference on cancer research, year: 2006
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p53 induces differentiation but not apoptosis of v-myb-transformed monoblasts
International Journal of Molecular Medicine,, year: 2006
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Panton - Valentine leukocidin positive <I>Staphylococcus aureus</I> strains isolated in the Czech Republic in 2004 - 2006
12th International Symposium on Staphylococci & Staphylococcal Infections, year: 2006
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PIN proteins perform a rate-limiting function in cellular auxin efflux
Science, year: 2006, volume: 2006, edition: Apr 6
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Plant telomere-binding proteins
Biologia Plantarum, year: 2006, volume: 50, edition: 1
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Počítání chromozomů
Year: 2006, type: Exposition
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Použití metod SSCP a TGGE pro screening kandidátních genů LQTS
X. Pracovní setkání biochemiků a molekulárních biologů, year: 2006
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Predikce klinického projevu reakce štěpu proti hostiteli po allogenní transplantaci kostní dřeně s využitím proteomických přístupů
XX. Olomoucké hematologické dny s mezinárodní účastí, year: 2006
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Preimplantation genetic diagnosis for Duchenne muscular dystrophy (DMD) by fluoresent in situ hybridization (FISH): case report
European Journal of Human Genetics, year: 2006
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Prevalence of vancomycin-resistant enterococci in hospitalized patients and those living in the community in the Czech Republic
The New Microbiologica, year: 2006, volume: 29, edition: 2