Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1209
2006
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Re-exprese nestinu v nádorově transformovaných buňkách: in vitro studie na vybraných typech nádorů
II. Dny diagnostické, prediktivní a experimentální onkologie, year: 2006
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Regulace aktivity osteoklastů: prostor pro terapii některých onemocnění kostí
Časopis lékařů českých, year: 2006, volume: 145, edition: 8
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Restrikční mapování blízce příbuzných spirochet rodu Treponema.
Year: 2006, type: Conference abstract
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Retinoic acid affects the response of v-Myb-transformed monoblasts to okadaic acid
Haematologica/the hematology journal, year: 2006
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Role of vimentin in regulation of monocyte/macrophage differentiation
Differentiation, year: 2006, volume: 74, edition: 6
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Různorodost výskytu kmenů Borrelia burgdorferi sensu lato u Ixodes ricinus na lokalitě Brno-Pisárky (1996-2002).
Year: 2006, type: Conference abstract
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Sedm let působení společné Laboratoře molekulární cytogenetiky Přírodovědecké fakulty MU a Oddělení lékařské genetiky ve FN Brno
Nemocniční listy, year: 2006, volume: 7, edition: 1
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Sekvenace heterologních oblastí genomu T. pallidum sussp. pertenue kmene Samoan D: cesta ke kompletní genomové sekvenci původce yaws.
Year: 2006, type: Conference abstract
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Sledování prevalence a variability Borrelia burgdorferi s.l. spirochet a jejich identifikace u hematofágních členovců a obratlovců v ČR v roce 2000-2003
Year: 2006, type: Conference abstract
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Současné trendy molekulární cytogenetiky v klinické genetice a onkologii
Nemocniční listy, year: 2006, volume: 17, edition: 4