Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1205
2006
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Zmapovanie interakcií kolicínov U a Y s receptorom OmpA.
Year: 2006, type: Conference abstract
2005
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2',4'-Dihydroxy-3-methoxy-alpha,beta-dihydrochalcone and 2',4-dihydroxy-alpha,beta-dihydrochalcone: supramolecular structures formed by O-H...O, C-H...O and stacking interactions
Acta Crystallographica Section C: Crystal Structure, year: 2005, volume: C61, edition: 6
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4-(Diethylamino)salicylaldehyde
Acta Crystallographica Section E: Structure Reports Online, year: 2005, volume: 61, edition: 12
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A new sensitive method for enzyme studies of rare glucosides
Biologia Plantarum Supplement to vol. 49, 2nd International Symposium Auxins and Cytokinins in Plant Development, year: 2005
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Actin-binding domain of mouse plectin. Crystal structure and binding to vimentin
1873-84, year: 2005, volume: 271, edition: 10
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Addressing the role of vimentin in monocyte/macrophage differentiation using RNAi approach
RNA club, year: 2005
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Allium cepa possess proteins able to bind the human- and Arabidopsis-type of telomeric sequence
Year: 2005, type: Conference abstract
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Analysis of histopathologic and molecular genetic findings in Czech LGMD2A patients
Neuromuscular disorders, year: 2005
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Analysis of plant telomere-binding proteins
The FEBS Journal, year: 2005
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Analysis of SMN gene regions in patients with spinal muscular atrophy
Functional genomics and disease, year: 2005