Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1207
2005
-
Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts
Journal of Applied Biomedicine, year: 2005
-
Biological effects of benzo[c]phenanthridine alkaloids.
Journal of Applied Biomedicine, year: 2005
-
Capillary Electrophoresis Combined with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry and Native Fluorescence Detection for Protein Analysis
Year: 2005, type: Conference abstract
-
CBP sensitizes v-myb-transformed monoblasts to differentiation inducers
Differentiation, year: 2005, volume: 73, edition: 5
-
Cílené genetické a epigenetické modifikace leukemických buněk
Year: 2005, edition: Vyd. 1., number of pages: 94 s.
-
Cílené zásahy do genové exprese a jejich využití při léčbě nádorů
Biologické listy, year: 2005, volume: 70, edition: 4
-
Comparing genomes of pathogenic and non-pathogenic spirochetes: DNA-microarray hybridizations, whole genome fingerprinting and DNA sequencing.
Year: 2005, type: Conference abstract
-
Comparison of different kinds of probes used for analysis of variant telomeric sequences
Biophysical Chemistry, year: 2005, volume: 117, edition: 3
-
Comparison of the genomes of pathogenic treponemes, Treponema pallidum ssp. pallidum, ssp. pertenue and Treponema paraluiscuniculi.
Clinical Microbiology and Infection, year: 2005
-
Complexation between vanadium (V) and phenyllactate: Synthesis, spectral studies and crystal structure of (NEt4)(NH4)3[V2O2(O2)2(R-3-phlact)2][V2O2(O2)2(S-3-phlact)2].6H2O, [3-phlact = 3-phenyllactato(2-)]
Inorganica Chimica Acta, year: 2005, volume: 358, edition: 13