Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1207
2005
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Genetic and molecular analysis of new sources of resistance to powdery mildew in barley (Hordeum vulgare ssp. spontaneum)
Book of Abstracts, 6th International Symposium in the Series Recent Advances in Plant Biotechnology, 12.-16.9.2005, year: 2005
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Genetic mapping and DNA markers for gene identification in Arabidopsis thaliana
Book of Abstracts, 6th International Symposium in the Series Recent Advances in Plant Biotechnology, 12.-16.9.2005, year: 2005
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Genetická determinace délky vegetativní fáze u modelové rostliny Arabidopsis thaliana.
Biologické listy, year: 2005, volume: 70, edition: 4
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Genomic imbalance detected in glioblastoma multigorme using high-resolution comparative genomic hybridization
Chromosome Research, year: 2005
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Genomics of Treponema.
Year: 2005, type: Conference abstract
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Genomika bakteriofágů
Informační listy Genetické společnosti Gregora Mendela, year: 2005, volume: 29, edition: 1
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Genomová amplifikace a restrikční mapování patogenních spirochet rodu Treponema.
Year: 2005, type: Conference abstract
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Genomová hybridizace kmenů T. pallidum Nichols a SS14 na oligonukleotidovém čipu
Year: 2005, type: Conference abstract
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Genotypová charakterizace TSST-1 pozitivních kmenů <I>Staphylococcus aureus</I> zachycených v ČR během let 1986 - 2004
XIV. konference mladých mikrobiologů Tomáškovy dny 2005 - sborník abstraktů, year: 2005
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High resolution comparative genomic hybridisation analysis for detecting small constitutional chromosome abnormalities
European Journal of Human Genetics, year: 2005